Here's a quick and easy way to start researching anything interesting in such photos (it might sound long and hard, but is actually the opposite once you get the hang of it):--
AS17-146-22293 is a lunar surface photo, and the "AS17" says it was taken during Apollo 17. (The second number is the film number, and the third is the frame number on that film. So...
1. Pick up the frame number and save it, or memorise it (in this case, 22293).
2. Go to the Apollo Lunar Surface Journal:--
https://www.hq.nasa.gov/alsj/3. Click on the top graphic which brings up another graphic with links to all the moonlanding missions -- Apollo 11 to Apollo 17,
4. Click on Apollo 17.
5. Page down past the wealth of information that's available about EVAs until you come to "Background Material".
6. Look down until you see "Image Library".
7, Click on it.
8. Start a search (Ctrl-F if you're an old-time computer-user like me) and paste in the number, 22293.
9. With almost indecent speed, artificial intelligence will rush you to whatever is initially available about that frame. See if it tells you anything useful. If not, study lines above and below, just in case. (However many lines is your choice.)
10, If still no luck, see if there's a time link to the appropriate spot in the Lunar Surface Journal. In this case, there is. 165:49:31. Click on it.
11. You are instantly told that: [{Ed} Fendell {the guy back in Houston controlling the TV camera on the Rover} finds Gene {Cernan} downslope of the Rover. He has the core {sampler, probably, or if not, an actual in-ground core} in hand and is leaning forward into the slope. He has taken a couple of pictures of Jack {Schmitt, the only professional geologist to ever step on the moon}], still taking 500{mm lens telephoto shots} from against the rock {to minimise camera-shake}. These are 22293 and 22294. {The ones Gene took, not Jack's telephoto shots}]
By paging up a little you'll find some links to that video, in this case immediately above 165:46:46 is:--
Video Clip ( 3 min 36 sec 0.9 Mb RealVideo or 35 Mb MPEG ) -- with hot links.
And there you are. (Most hoax-believers know none of this stuff.)
There's no mention of the anomaly in 22293, but sometimes there IS a mention in a few of the thousands of other photos taken on the lunar surface.
There's not even a mention of the interesting blue anomaly to the right of Jack Schmitt in frame 22294. It looks a little like a head-on comet with a spherical head and broad trailing tail.
One or two of the Apollo 11 colour photos have tiny, circular, very bright blue anomalies on the right hand edge. Like Zakalwe in reply #5 above, I have also heard that some of those things might be cosmic ray strikes, but I don't know whether that's just a cool-sounding wild guess or a professional and scientifically-valid comment.
Nasa was so finicky about documenting everything that I'm surprised that I've never heard of a 400-to-1000-page report that fully documents every anomaly found in all the Apollo photos.
But I never heard either from anyone else about the one thing I commented on as a result of being an amateur photographer in the 60s and professional (and black-and-white printer) in the 70s and 80s:-- That many of the severely-fogged early black-and-white Apollo prints (which can be seen in Michael Light's book "Full Moon", Jonathan Cape, London, 1999) were possibly fogged by a darkroom worker who smoked in his darkroom and eventually coated his enlarger lens with cigarette smoke and tar. I say it's a "he" because in my experience, female printers were usually far better at their job than male printers and far too smart to stuff up their brilliant work with cigarette smoke. But I could be wrong. :-)