It'd be hard enough to replicate what we see on videos of the Apollo lunar EVAs, but we don't have any video or film at all of astronauts in the LM cabin, in 1/6 g and out of their suits. The best we have are short clips of synthetic 1/6 g on airplanes (e.g., Mythbusters), but even that's not totally accurate since the planes don't fly an exact path (small control errors, turbulence, etc). You can sometimes see this problem in scenes in Apollo 13 where a floating object (or actor) starts moving or takes a turn for no reason. You could eliminate this effect by having the entire set float within the airplane cabin as long as the plane flies the parabolic path accurately enough to keep the set from contacting the cabin interior. But you can't do that during synthetic 1/6 g.
So... how do you do scenes like the conference room on the moon in 2001? Even today nobody even tries to replicate lunar gravity in interior sets of movies set on the moon, e.g., Moon.
What amused me was how Moon and other films copied the look of old cheesy SF shows like Space 1999 in depicting normal earth gravity inside the lunar base, but as soon as anybody goes outside they move in slow motion.