I've often wondered why Grumman chose to go with separate descent and ascent engines. It always seemed to be a lot of extra mass that you could shed just by leaving a hole in the bottom of the descent stage as in this design. I have read Kelly's Moon Lander but I don't recall his addressing that specific design choice.
One possibility I can think of (and again, I'm not an engineer) is that it might have been a more 'comfortable' proposition to have a plane of separation between the two stages rather than having the engine poking through a hole in the descent stage, as in the Convair design. In the event of an abort you'd have to be sure of a clean withdrawal of the engine through the hole.
ka9q mentioned redundancy, and it's possible that the convair design may have morphed to having separate ascent and descent engines had it been carried forward. They already have the 'standby thrust chambers' there, so it doesn't seem like a huge step to put the big engine on the descent stage instead and save weight on the ascent stage. That would also remove the need to sever fuel lines between the two stages on staging.