Well, a couple of factors interact. Basically, the 180° is relative to the point of LOI, so that's less critical. You launch into an Earth orbit that's already in a plane where you want the transfer orbit by adjusting the time of launch and direction. After that, wait until the right time, then fire the third stage, and the resulting orbit will take you to the moon.
The real issue is that the orbit must also intersect the moon's orbital plane near apogee. Since the Earth orbit is inclined, you can adjust it north or south by timing the TLI burn, but there's definitely times that are more optimal. There's also room for course correction during the lunar transit.
Finally, the issue was combining it so that the landing will take place during lunar morning.
Most of you probably know this, but lunar morning was chosen for two reasons; one, the long shadows would enable the commander to avoid any large boulders or other hazards during landing, and two, the LM was designed to maintain a reasonable working temperature during lunar morning. This also meant that the rear of the spacecraft always faces the sun in the pictures.
(I'm probably repeating other posters, but sometimes it helps to formulate things in different words)